Purpose: Soft tissue liners are used for healing of abused oral tissues. They may harbour microorganisms causing oral diseases such as candidiasis compromising the health of the patient. Also, addition of antifungal agents into soft tissue liner may alter its properties. This study compares tensile bond strength and antifungal properties of soft tissue liner containing different antifungal agents. Methods: 2 Antifungal agents, ketoconazole and voriconazole were added into the soft tissue liner (permasoft). The tensile bond strength of permasoft with poly methyl meth acrylate with and without antifungal agents were assessed. Antifungal efficacy of permasoft containing these antifungal agents were assessed on 1st, 3rd ,7th ,15th and 30th day. Results: Maximum tensile bond strength was found to be of permasoft alone (control). While, the highest antifungal activity was shown by permasoft containing ketoconazole.Conclusion:The ketoconazole in the soft tissue liners can be used as an effective treatment option for c.albicans, then the systemic or topical antifungal agents.