Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
In this study, an environment friendly, one-pot method is used to synthesize immine derivative (E)-8-((furan-2-ylmethylene)amino)-4-methyl-7-oxo-2-thiabicyclo[4.2.0]oct-4ene-5-carboxylic acid from renewable lignocellulosic biomass furfural and 7-ADCA. Furfural derived from lignocellulosic biomass plays an important role in this environment friendly approach. This process is based on the principles of green chemistry, especially the use of ethanol as a solvent reduces the environmental impacts associated with conventional synthetic methods. The chemicals and processes utilized, highlights a sustainable practice in pharmaceutical research and are aimed at using 7-aminodeacetoxy cephlospornic acid (7ADCA) and furfural for the synthesis of Schiff Base (FA). The synthesized imine derivative (FA) was characterized using various analytical techniques such as melting point, FT-IR, NMR and SEM. The derivative appeared to be a brown coloured fine powder having melting point 170°C and average particle size 450nm with agglomerated form and spherical shape. The yield was calculated to be 64%. Systematic screening of the synthesized imine showed promising antioxidant activity by phosphomolybdenum assay and In-Vitro antibacterial assay exhibited bactericidal activity against a variety of gram-positive and gram-negative bacteria. These studies not only appear to provide strategies for manufacturing sustainable products also promotes sustainable practices in pharmaceutical research and explores the ways in which furfural-derived imines can be used in pharmaceutical and materials science.