Background: The healthcare work environment is surrounded by health hazards that only present in healthcare sector. These hazards reflect on menstruation, causing premature rupture of membranes or abortion that negatively affects the reproductive health of female nurses. Aim of study: the study aims to assess the effect of work environment on reproductive health of female nurses. Subjects and methods: A descriptive retrospective design used to achieve the aim of the study. The study conducted in Diarb Negm hospital in Elsharkia governorate. Convenient sample used in this study. Two data collection tools were used in the study, a structured interview questionnaire and observational checklist.