Introduction: The common name of Tridax procumbens used by practitioners of ayurveda is bhringraj. It has a number of pharmacological properties including hepatoprotective, wound healing and immunomodulating properties. The leaves of T. procumbens have always promised to be a great source of antimicrobial compounds. The nanoparticles synthesized in our study are silver nanoparticles which are known to be safe to mankind and have shown to have little to no allergic reaction when tested for curing various diseases. Due to their distinctive physical and chemical characteristics, silver nanoparticles are being employed more and more in a variety of industries, including medicine, food, health care, consumer goods, and manufacturing. The aim of this study is to prepare T. procumbens leaves mediated silver nanoparticles and analyze its antimicrobial properties. Materials and Methods: T. procumbens leaf extract was prepared and then it is used to synthesize silver nanoparticles. Colour changes were observed at regular intervals during the synthesis process and characterisation was done using UV-vis spectroscopy, SEM, EDAX and FTIR. The antimicrobial activity was evaluated by well diffusion assay at different concentrations against more common oral pathogens such as S. aureus, P. auruginosa and compared with that of the standard drug. Results: The silver nanoparticles synthesized using T. procumbens in this study were observed to show enhanced zones of inhibition against S. aureus (23±0.32mm) and P. auruginosa (20±0.32mm) at 100μL concentration when compared to standard. Conclusion: T. procumbens mediated silver nanoparticles showed potent antimicrobial activity against common oral pathogens. Hence these nanoparticles can be used as antimicrobial agents in various nanoformulations for oral diseases.