Background: Nursing is an occupation known for experiencing high rates of burnout, with nurse burnout defined by various factors such as physical, psychological, emotional, and social exhaustion resulting from job stress and limited support. The prevalence of nurse burnout globally ranges from 11.2% to as high as 68.0%, with post-COVID-19 era exacerbating the issue. Various factors contribute to burnout, including excessive workload, lack of staffing, role conflict, and more. Nurse burnout not only affects nurses negatively but also impacts patient care quality and healthcare organizations. Previous research has focused on describing nurse burnout, its prevalence, risk factors, and related outcomes, emphasizing the need for effective prevention and intervention strategies tailored specifically for nurses. Objective: This research aims to evaluate the prevalence and severity of nurse burnout in a specific healthcare setting, identify contributing factors like workload, support deficiency, and work-life balance, explore the impact of nurse burnout on patient care outcomes, job satisfaction, and retention rates, and to assess the effectiveness of current interventions in place to prevent and manage nurse burnout. Conclusion: Nurse burnout is a critical issue affecting both nurses and patient care quality, influenced by factors like workload, lack of support, and poor work-life balance. Effective interventions such as creating supportive environments, promoting work-life balance, offering mental health resources, and implementing specific programs like mindfulness training are crucial in addressing nurse burnout. The costs associated with nurse and pharmacist burnout emphasize the necessity of proactive measures to support nurses and ensure high-quality care. By investing in nurses’ well-being and fostering a culture that values their contributions, healthcare organizations can mitigate the negative impacts of burnout, benefiting both patients and healthcare providers.