The aim of the research is to improve micromeritic properties and oral bioavailability CH by liquisolid technique.Cinacalcet hydrochloride (CH) is a calcimimetic drug approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD.) The major problem associated with CH is its poor aqueous solubility and low bioavailability (20-25 %). The objective of this research is to improve the micromeritic properties, dissolution rate and biopharmaceutical attributes of CH via liquisolid technique.CH liquisolid compacts were formulated using tween 80 as the non-volatile solvent, neusilin US2 as the carrier material, aerosil as the coating material. Fourier-transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), powder X-ray diffraction (P-XRD) study performed. Pharmacokinetic study was performed in albino rabbits for checking the enhancement potential of biopharmaceutical attributes of the selected liquisolid formulation.Liquisolid formulation exhibited improvement in micromeritic properties FT-IR and DSC confirmed no drug-excipient interaction. P-XRD study revealed presence of CH in porous carrier in dissolved state.