ISSN 2063-5346
For urgent queries please contact : +918130348310

Histomorphological and immunohistochemical study on lung carcinoma

Main Article Content

Dr. Tejasvini Chauhan,Dr. Jyoti Mishra,Dr. Salony Mittal,Dr. Devendra Kumar Singh,Dr. Vatsala Gupta,Dr. Prachi Saxena
» doi: 10.31838/ecb/2023.12.si6.010


Accurate subtyping of lung carcinomas requires the use of immunohistochemistry along with histopathology in small biopsies. This forms the basis of targeted therapies. In this study, we classified lung biopsies morphologically and immunohistochemical. Materials and methods: All lung biopsies received in 10 % NBF from January 2017 to May 2022 in the Department of Pathology, School of Medicine and Research, Sharda University, Greater Noida were studied. Histological diagnosis was rendered on H&E. The doubtful cases were subjected to IHC p63, TTF- 1, and chromogranin with positive controls. Results: The age of patients ranged from 32 to 82 years with male predilection. The most common symptom was cough (27.3 %), followed by hemoptysis, dyspnoea, and chest pain. Out of forty cases of lung carcinomas 20 cases of NSCLC (out of which 13 were of AC and 7 were SCC). Eight cases of small cell carcinoma. Twelve cases were of poorly differentiated carcinomas. Twelve cases of poorly differentiated carcinoma were subjected to immunohistochemistry (TTF-1, p63 and chromogranin). TTF-1 positive 5 cases were further classified as AC, p63 positive 3 cases as SCC and 3 cases expressed chromogranin A positivity as small cell lung carcinoma. One case did not express positivity for any immunohistochemical marker and was labelled as undifferentiated carcinoma. Conclusion: The present study gives the glimpse of the histological subtypes of lung carcinoma in the Delhi-NCR region over the period of past 5 years diagnosed on histomorphology and immunohistochemistry.

Article Details