Thiocolchicoside is used for the controlling the painful muscle spasm in the cervical spondylitis and arthritis. Thiocolchicoside was found to be compatible with Eudragit L100 and HPMC and they were used in the formulation. The flux of the Thiococolchicoside was found to be 30µgm/cm2 /hr and calculated dose in the patch was about 16.36mg per patch for providing the release over 48hrs. Ginger oil along with DMSO, oleic acid and ginger oil was investigated for the permeation enhancement. Ginger oil at 4% provided the highest flux of 41µgm/cm/hr over 24hrs on 1% solution of drug. The effect of adhesive on the permeation of the drug was also investigated and Dura Tak-87-6908 was selected & used as the adhesive in the formulation. The bioadhesivity evaluation apparatus was developed and force transducers. The formulation was optimized with full factorial design and the final batch was formulated and tested for all quality control parameters. The final formulation was casted on the pilot scale lab coater developed in the studies. The prepared batch was also tested for the skin irritation and sensitization. The final preparation was tested for stability at 40°C±5°C and RH 75% and it was found to be stable in the stability studies