In systemic and oral diseases, salivary alpha amylase is used as a biomarker. Salivary amylase is elevated in these diseases to play a protective role during the inflammatory stage because all systemic and periodontal diseases are chronic inflammatory diseases. Objective: To evaluate the salivary amylase concentration as inflammatory biomarker in chronic periodontal disease patients. Methodology: 160 subjects were allocated into groups I, II, III, and IV (40 healthy controls, 40 generalized chronic gingivitis, 40 localized and 40 generalized chronic periodontitis). Saliva that had not been stimulated was collected, and amylase was estimated using the kinetic assay method. Independent t-tests, post hoc Tukey, and ANOVA were used to analyze the results. Results: In this study, generalized chronic gingivitis, localized chronic periodontitis, and generalized chronic periodontitis all had significantly higher salivary amylase levels than healthy controls (p<0.001). Salivary amylase level was a bit more in women as compared to men. Conclusion: It is concluded that patients with chronic periodontal disease had higher concentrations of salivary alpha amylase than did periodontally healthy controls. Salivary alpha amylase level concentration was slightly higher in females than male subjects.