Ethnomedicines play an important role in the health-care practices of the Traditional Knowledge holder of Yadagiri district of Karnataka. The ethno-botanical exploration was conducted at nearby villages of forests to document and identify potential plant species for phytochemical and pharmacological studies. About 75 species of all life form belonging to 40 genera and 40 families were documented. In most of the cases, single plant was useful in curing two to three diseases such as leucorrhea, fever, jaundice, rheumatic pains, menstrual disorders, cuts and wounds. A good number of claims have also been recorded. The parts used and the method of herbal preparation was discussed along with the local names. The most of the medical claims made here are new to the field of ethnomedicine. Those plants which received high citation frequency may prove helpful for further studies. In this article, the effort which made to identify the persons with proven knowledge of local biodiversity; and document. A special attention has given to the elderly persons who can also provide information on the biodiversity which was available in the past but no longer seen at present