Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Objective- This research intends to construct and evaluate novel Diclofenac sodium gastro- retentive effervescent floating tablets. Method- The basis for the floating tablets was the effervescent method, which utilized Citric acid and bicarbonate sodium as a source for the gas. A direct compression system is used to develop the tablets with effervescence. The polymers and drugs applied to the formulation underwent FTIR research. Drug release profile and floatation behaviour have been investigated for several polymers including HPMC K100 LV, Chitosan, Guar gum, Xanthan gum, and Carbopol 934P. A standard calibration curve was plotted using Diclofenac sodium with HCL (0.1N) and phosphate buffer (pH 6.8). After formulation, the tablets were subjected to post- formulation investigations, which evaluated their organoleptic properties, drug content, hardness, thickness, weight variation, and friability. Pre-formulation analyses were performed, including solubility, tapped density, Hausner ratio, bulk density, compressibility index, and repose angle.