The present study involves preparation and evaluation of floating microballoons of Repaglinide for improving the bioavailability. Microballoons promises to be a potential approach for gastric retention time in the gastrointestinal tract (GIT) they are designed to overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug by controlling release rate for drugs. The Microballoons were prepared by Solvent Evaporation technique using polymers such as Ethyl Cellulose, Hydroxy Propyl Methyl Cellulose along with solvents like alcohol, dichloromethane and Surfactant like Tween 80 to decrease the interfacial tension between fluids. The optimization of microballoons was done by using Design of Experiments (DoE) studies Box-Behnken design is utilised for the same.Prepared microballoons were analyzed for their Percentage Buoyancy (PB), Mean Geometric Diameter (DG) and Entrapment Efficiency (EE).In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method.In vitro drug release of the optimised formulation was found to be 95.48 %. The prepared microballoons exhibited prolonged drug release i.e. Upto 12 hours. Stability studies was carried out at 40 ± 2°C Temp and 75 ± 5% Relative Humidity shows no significant change in microballoons of the optimized formulation after 06 months of storage.