Climate change poses a significant threat to global food security, with rising temperatures and changing precipitation patterns impacting crop yields and sustainable agriculture. This review paper provides a comprehensive overview of the chemistry of climate change in the context of agricultural production, discussing the effects of global warming on crop growth, productivity, and nutritional value. The paper examines the role of agricultural chemistry in mitigating the impacts of climate change, including strategies for reducing greenhouse gas emissions, improving soil health, and developing climate-resilient crops. The paper highlights the chemical and biochemical processes affected by rising temperatures and changing precipitation patterns, including photosynthesis, respiration, and nutrient cycling. The impact of climate change on crop yields, nutritional value, and food security is analyzed, with a focus on the most vulnerable regions and populations. The review also discusses the potential of sustainable agricultural practices, such as organic farming, agroforestry, and conservation agriculture, to reduce greenhouse gas emissions and improve soil health. The development of climate-resilient crops through genetic engineering and breeding is also explored, as well as the potential for biofertilizers and biopesticides to reduce the environmental impact of agricultural production. The paper concludes with a call to action for researchers, policymakers, and agricultural practitioners to address the challenges of climate change and ensure a sustainable food future. The review provides a valuable resource for understanding the complex relationships between agricultural chemistry, climate change, and food security, and highlights the need for interdisciplinary approaches to address these global challenges.