HIV/AIDS should always be treated for the remainder of their lives with influential life-saving drugs such as nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors. HIV/AIDS remains a major global public health problem, having claimed the lives of 40.1 million [33.6-48.6 million] people to date. In 2021, 650 000 [510 000-860 000] people may have died from HIV-related causes, and 1.5 million [1.1-2.0 million] will have become infected. HIV infection has no cure exists. There is currently no cure for HIV/AIDS. Once infected, your body is unable to rid itself of it. There are, however, innumerable medications that can control HIV and prevent complications. These drugs are known as antiretroviral therapy (ART). Based on their molecular mechanism and resistance profiles, these drugs are separated into six distinct classes: (1) Reverse transcriptase inhibitors predicated on nucleoside aptamers. Just before to 1996, there had been few antiretroviral treatment options for HIV-1 infection. Prophylaxis against common opportunistic pathogens and management of AIDS-related illnesses composed the major part of HIV-1 clinical management. The development of inhibitors of reverse transcriptase and protease, two of HIV-1's three essential enzymes, and the introduction of drug regimens that combined these agents to increase overall efficacy and durability of therapy reinvented the treatment of HIV-1 infection in the mid-1990s. A timeline for both the development and approval of antiviral drugs for human use.