The Purpose of this study was to evaluate and compare the efficacy of benzocaine, meloxicam and diclofenac in reducing pain caused by elastomeric separators. Materials and methods: A sample size of 60 patients coming to Department of Orthodontics and Dentofacial Orthopaedics for orthodontic treatment were included in the study. Elastomeric separators were placed mesial and distal to first maxillary molars in both quadrants. And half an hour later the drug mucoadhesive patch and the placebo mucoadhesive patch were randomly placed on buccal mucosa above the 1st maxillary molar, among 20 patients each in three groups. For both the quadrants, the patients were given Visual Analogue Scales (VAS) and Numerical Rating Scales (NRS). The Mann-Whitney U test and Krausal test analyses were done after data collection. The patients marked readings every six hours beginning 30 minutes after the patch insertion. The mucoadhesive drug and placebo patch was replaced after 48 hours and every six hours, the reading was remarked, and the final marking was conducted at 72nd hour and mucoadhesive patch was replaced. Results: There was statistically significant reduction in pain , when the mucoadhesive drug patch was compared with that of the placebo patch. It was seen that benzocaine was most effective at 6th, 48th ,72nd hour, followed by meloxicam which was also effective at 6th, 48th ,72nd hour and diclofenac effective at 6th , 12th ,18th ,48th 72nd hour .When all the three drug patches were compared, it was observed that benzocaine was significantly more effective in relieving pain caused due to separators. Conclusion: It can be concluded from the study that the mucoadhesive drug patches are significantly effective in reducing pain caused by elastomeric separators as compared to the placebo patch. The use of benzocaine patches was most effective followed by a meloxicam mucoadhesive patch and diclofenac.