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ISSN 2063-5346
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VITAMIN D LEVELS IN CHILDREN WITH EPILEPSY ON ANTI-SEIZURE MEDICATIONS(ASM)

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Sanjay chavan, Shiji Chalipat, Devika Ulhasrao Jadhav, Muhammed Fajas c. v, Shailaja Vijaykumar Mane, Renuka S Jadhav, Shalaka Agarkhedkar
» doi: 10.31838/ecb/2023.12.s2.063

Abstract

Aim: To asses effect of Anti-seizure medication (ASM) on vitamin D3(25- hydroxy vitamin D) levels and calcium profile in children with new onset epilepsy Materials and methods: This study was a prospective observational study.Children fulfilling inclusion criteria were enrolled in the study after getting informed consent from the parents in the language they understood. Children age group 1-15 years of both genders attending pediatric Opd/Pediatric neurology opd/admitted in ward diagnosed with new onset epilepsy as per ILAE -2017 definition who were going to be started on Anti seizure medication (ASM). Results: The study determined the effect of Vitamin D levels in children with epilepsy on Anti seizure medications(ASM) . The Mean vitamin D level, post Treatment (18.489 ± 5.2) as compared to preTreatment (24.670 ± 4.1) were significantly lower (p <0.001). Vitamin D insufficiency was detected in two thirds of the children after 6 months of anti-seizure medication usage. The study found that, all 9 children (100%) on oxcarbazepine monotherapy and 2 children on sodium valproate monotherapy had Vitamin D3 insufficiency while all 10 (100%) children on Levetiracetam monotherapy had normal vitamin D levels. The mean levels of calcium and phosphorus decreased while the mean levels of ALP increased following ASM, both of which were statistically significant (p <0.001). Conclusion: Current study revealed that there is significant decrease in vitamin D3 levels after 6 months of initiation of anti-seizure medication. we found a significant association between type of anti seizure medication and vitamin D levels as well. Oxcarbazepine, which is an enzyme inducer was strongly associated with low vitamin D3 levels .Sodium valproate, which is an enzyme inhibiting effect, has also found to be strongly associated with low vitamin D3 levels

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