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ISSN 2063-5346
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USE OF HYDROGELS AS CONTROLLED DRUG RELEASE SYSTEMS IN BREAST CANCER

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Vera-Tapia Alexis1*, Silva-Yumi Jorge2,3, Aguilar Reyes Johanna3, Coello-Cabezas Julio4, Mejía Nora5, Ormaza Rosa2,3
» doi: 10.48047/ecb/2023.12.5.245

Abstract

The leading cause of death in women worldwide is breast cancer, considered the first most common type of cancer and the fifth most deadly. Current treatments include surgery, chemotherapy, radiotherapy, brachytherapy and hormone therapy, however, these therapies cause side effects in patients such as pain, nausea, vomiting, cytotoxic effects on normal cells and damage to different organs and tissues, and in many cases there is tumor recurrence due to residual malignant cells. Therefore, it is necessary to look for a type of therapy that acts specifically on the tumor area, is effective and does not cause the side effects mentioned above. Hydrogels have emerged as an alternative for the treatment of cancer, due to their properties and the localized action that can be achieved with them. The aim of this review is to determine the response of hydrogels to different external factors and the effect on drug release on cell lines. For this we have searched and collected articles using the keywords: hydrogels and breast cancer, through: ScienceDirect, Google Academic, Springer, Scholarpedia, PubMed and Taylor and Francis. The information discussed will be very useful to guide improvements in future research on hydrogels for the treatment of breast cancer.

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