Animal-derived anticancer drugs have been used in cancer treatment for many years. These drugs are derived from various animal sources such as marine organisms, amphibians, snakes, and mammals. They have shown promising results in the treatment of various types of cancers, including leukemia, lymphoma, breast cancer, and lung cancer. Many of these drug’s work by inhibiting cell division or inducing apoptosis in cancer cells. They have also been shown to have fewer side effects compared to conventional chemotherapy drugs. However, the development of animal-derived anticancer drugs faces various challenges, including the limited availability of the sources, ethical concerns, and difficulties in isolating and synthesizing the active compounds. Here in this review bleomycin, cytarabine, eribulin, and ziconotide of animal derived anticancer drugs were discussed in detail. Nonetheless, continued research in this field has the potential to lead to the discovery of novel and effective anticancer drugs from animal sources