This study is going to research the role of registered nurses in fighting HIV/ AIDS in patients so that the responsibilities can be addressed in a systematic way as possible. The aim of the study is to determine the respective role of registered nurses to design the proper framework to initiate the treatment process and maintain the inputs throughout the treatment. The objectives of the study are being mentioned as to conduct the study in a systematic way to retrieve the justified knowledge and information regarding the present scenario. Methods and materials are being mentioned that assist the researchers to conduct the data collection and data analysis in a systematic way as possible, in this regard suitable methods and techniques have been chosen for the present study to evaluate the themes and patterns of the collected data. Here in the current study secondary data collection has been utilized to interpret the respective conditions in curing HIV patients. In the result and discussion, part findings are consulted through themes and patterns, and the causes of HIV transfer and AIDS are mentioned. Further, the role of the registered nurse in different dimensions has been mentioned according to the study. Issues faced by nurses are to be taken into consideration to curtailing the further progression of cases.