Background: Surgery is offered to patients with Graves’ disease (GD) refractory to medical or radio-iodine therapy. Total thyroidectomy (TT) has been shown to lower recurrence rates of hyperthyroidism because the whole thyroid tissue is removed but subtotal thyroidectomy (ST) is thought to be associated with lower risk of postoperative complications. Aim and objectives: To compare between the two techniques regarding postoperative recurrence of hyperthyroidism, hypocalcemia and hypoparathyroidism. Subjects and methods: This was prospective controlled clinical trial, was carried out at Department of General Surgery, Assiut University Hospital, Assiut, Egypt on 80 patients were allocated randomly to one of the treatment groups Group TT And Group ST With a 1: 1 ratio, during two years duration (2020-2021), Result: There were significant difference between both groups as regard recurrent hyperthyroidism. Conclusion: With our findings demonstrating lesser relapse of hyperthyroidism and similar safety profiles of TT in tandem with a high proportion of patients eventually needing thyroxin replacement after ST, we believe that TT should be the surgical procedure of choice for patients with GD. We find little reason to continue to offer ST as an alternative.