The aim of this research is to investigate the changes in renal volume and function that occur after unilateral nephrectomy. Material and Methods: This is a prospective study, observational study, and cross-sectional study of all of the patients who receive nephrectomy at tertiary care hospitals for kidney transplantation, cancer, and other renal illnesses. Throughout the course of the research, a total of one hundred individuals who had a nephrectomy performed either openly or laparoscopically were evaluated. Each patient's complete medical history has been meticulously documented. Results: Of them, 23 were performed as part of a kidney donation, 25 were performed due to renal cancer, and 52 were performed due to disease. We had three patients with tuberculosis, seventeen with pelviureteric junction obstruction, seven with xanthogranulomatous pyelonephritis, six with emphysematous pyelonephritis, seventeen with pyonephrosis, one with angiomyolipoma, and one with renal artery thrombosis among these 52 diseased nephrectomies. Nephrectomies including the donation of kidney tissue were performed on 23 patients, while radical nephrectomies were carried out on 25 individuals. The remaining 52 patients all had either a simple or subcapsular nephrectomy performed on them. Because of this, the majority of patients in our research were from a nephrectomy group for illness. Conclusion: The differences in the functional and volumetric outcomes after unilateral nephrectomy may be organised in descending order as follows: donor nephrectomy group, radical nephrectomy group, and finally diseased nephrectomy group.