The development of a solid lipid nanoparticle loaded with itraconazole was the aim of this investigation. The drug molecule's physiochemical and pharmacokinetic performance is constrained by the drug profile's poor solubility, toxicity, instability, incompatibility, and poor penetration. By using varied concentrations of different lipids and a hot homogenization procedure followed by an ultrasonication approach, itraconazole SLNs were created