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Three Step Synthesis and Characterization of novel -1,2,3-triazol-1-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile hybrids

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J.Sunil Kumar,Jagadeesh Kumar Ega
» doi: 10.31838/ecb/2023.12.si6.328


At first blend of 6-amino-1,3-dimethyl-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (4a-j) via Knoevenagel condensation and Michael addition, followed by tautomeric cyclisation and conjugation by using Zn (Proline)2 catalyst and then followed 6-azido-1,3-dimethyl-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (5a-j) by means of amine to azide conversion. Later on substituted (4-phenyl-1H-1,2,3-triazol-1-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (6a-j) were synthesized 1,3-dipolar [3+2] cyclo addition using Sharpless catalystwith promising yields depicted (Scheme I and tables 2-7) in this manuscript

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