More than 85 % yields of ten substituted 2-benzylidene-1-tosylhydrazines have been prepared by thionyl chloride assisted condensation of 1-tosylhydrazine and substituted benzaldehydes in room temperature. They are characterized by their physical constants, analytical, and spectroscopic data. The antimicrobial activities of these hydrazines were evaluated by Bauer-Kirby disc diffusion method.