The stress is a deviation from normal body and mental functioning. Workplace stress can develop for a number of reasons, such as job control, manager management style, etc. Moderate stress benefits both the business and the workforce. It assists in accomplishing both personal and organisational goals. Nonetheless, excessive stress can have detrimental effects on a person's physical well-being, mental state, and personality. By applying the psychological techniques that are involves questionnaires, stress can be measured. The primary goal of this study is to examine how work stress affects employees' performance on the job in the Chengalpattu district of Tamil Nadu's pharmaceutical industry. 300 people in total were contacted. Last but not least, the study's sample size is 276 employees. The sample is described using descriptive statistics, ANOVA, and post-hoc analysis. Stress at work has been demonstrated to be positively impacted by poor management abilities. The absence of competitive knowledge, weak risk-taking skills, inadequate training, a lack of expertise in the industry, excessive leisure time, and non-contact occupational mobility, on the other hand, have a negative effect on job stress.