Opioid misuse and addiction have become a critical public health issue worldwide, leading to devastating consequences for individuals, families, and communities. Pharmacists and nurses play a crucial role in addressing this crisis through education and harm reduction strategies. This review article examines the role of pharmacists and nurses in combating opioid misuse and addiction, with a focus on the impact of education and harm reduction initiatives. The review explores the various ways in which pharmacists and nurses can contribute to addressing opioid misuse and addiction, including through patient education, medication management, and collaborative care efforts. Additionally, the article discusses the importance of harm reduction strategies such as naloxone distribution, medication-assisted treatment, and overdose prevention programs in reducing the harms associated with opioid misuse. Furthermore, the review highlights the need for enhanced training and education for pharmacists and nurses to effectively address opioid misuse and addiction in their practice settings. By equipping these healthcare professionals with the necessary knowledge and skills, they can play a key role in early detection, intervention, and support for individuals struggling with opioid use disorders. Overall, this review underscores the critical role that pharmacists and nurses play in addressing opioid misuse and addiction through education and harm reduction strategies. By leveraging their expertise and resources, these healthcare professionals can make a significant impact in combating this complex public health issue and improving outcomes for individuals affected by opioid use disorders.