Background: The co-administration of food and drugs poses a significant concern due to potential interactions that can impact the efficacy and safety of pharmacotherapy. Understanding drug-food interactions is crucial for optimizing patient outcomes and preventing adverse events. Objective: This study aims to assess nurses' knowledge of drug-food interactions in hospitalized patients, evaluate the impact of educational interventions by clinical pharmacists on nurses' understanding, and analyze the effect of enhanced nurse education on the occurrence of drug-food interactions. Recommendations for integrating ongoing education on drug-food interactions into nursing practice are also developed. Conclusion: Nurses play a vital role in medication administration and patient education, making their understanding of drug-food interactions essential for patient safety. Enhanced nurse education on pharmacology and nutrition can lead to better identification and prevention of drug-food interactions, ultimately improving patient outcomes. Collaborative efforts between healthcare professionals, including pharmacists and dietitians, are crucial in addressing complex interactions and providing comprehensive care. Investing in nurse education on drug-food interactions is paramount for delivering high-quality, patient-centered care and reducing the incidence of medication errors in healthcare settings.