Background: Aging is a natural, multifaceted, progressive and inevitable phenomenon, adversely affecting the structural integrity and biological functions of the brain generally and the hippocampus specifically. It is a major risk factor for several neurodegenerative diseases such as Alzheimer’s disease, Parkinson's disease and dementia Aim and objectives: Study the effect of aging on the hippocampal-dependent learning ability and spatial memory in the adult and senile male albino rats by applying the behavioral test (Morris water maze test).