Sleep deprivation among nurses is a critical issue that has been shown to have significant implications for their performance and overall well-being. This review article examines the various ways in which sleep deprivation can affect the performance of nurses in clinical settings. The review synthesizes current research findings on the topic and highlights the key factors contributing to sleep deprivation among nurses, such as long working hours, shift work, and high job demands. Furthermore, the review explores the consequences of sleep deprivation on nurses' cognitive function, decision-making abilities, patient care, and overall job satisfaction. Strategies to mitigate the impact of sleep deprivation on nurses' performance are also discussed, including implementing fatigue management programs, promoting healthy sleep habits, and creating supportive work environments. By addressing the issue of sleep deprivation among nurses, healthcare organizations can improve patient outcomes, enhance workplace safety, and support the well-being of their nursing staff.