Diabetes is a prevalent chronic condition that requires ongoing management to prevent complications and improve quality of life. Nurse-led programs have gained recognition for their ability to provide comprehensive care, education, and support to patients with diabetes. This review synthesizes existing literature to evaluate the impact of nurse-led interventions on key patient outcomes, including glycemic control, adherence to treatment plans, quality of life, and healthcare utilization. The review includes studies from various settings, such as hospitals, primary care clinics, and community health centers, to provide a comprehensive overview of the impact of nurse-led programs on patient outcomes. Findings suggest that nurse-led interventions are associated with improved glycemic control, increased adherence to treatment regimens, enhanced quality of life, and reduced healthcare utilization among patients with diabetes. Nurses play a vital role in empowering patients to self-manage their condition through education, counseling, and ongoing support. Furthermore, the review discusses the potential barriers and challenges faced by nurse-led diabetes management programs, such as limited resources, lack of standardized protocols, and healthcare system constraints. Recommendations for optimizing the effectiveness of nurse-led interventions are provided, including interprofessional collaboration, patient-centered care approaches, and leveraging technology to enhance communication and monitoring. In conclusion, nurse-led diabetes management programs have a positive impact on patient outcomes and can help improve the overall management of diabetes. Future research should focus on evaluating the long-term effects of nurse-led interventions, exploring cost-effectiveness, and identifying strategies to overcome barriers to implementation. By highlighting the importance of nurse-led care in diabetes management, this review contributes to the growing body of evidence supporting the role of nurses in improving health outcomes for patients with diabetes.