Background: Electronic health records (EHRs) have become a widely adopted technology in healthcare, with the aim of improving patient care and outcomes. However, there is a need to examine the evidence on the impact of EHRs on patient outcomes. Objectives: To conduct a systematic review of the literature on the impact of EHRs on patient outcomes, including patient safety, quality of care, and patient satisfaction. Methods: A comprehensive literature search was conducted using multiple electronic databases, including PubMed, Scopus, and CINAHL. Studies were included if they were published in English, used a quantitative design, and examined the impact of EHRs on patient outcomes. Results: The search yielded 25 studies that met the inclusion criteria. The studies were grouped into three categories based on the outcome measured: patient safety, quality of care, and patient satisfaction. The results showed that EHRs have a positive impact on patient outcomes, including reducing medication errors, improving the coordination of care, and increasing patient engagement and satisfaction. Conclusion: The evidence from this systematic review supports the use of EHRs in improving patient outcomes. EHRs have the potential to improve patient safety, quality of care, and patient satisfaction, and their implementation should be continued and expanded. Further research is needed to explore the optimal use of EHRs and their impact on patient outcomes in different healthcare settings.