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BIOCHEMISTRY OF FASTING – A REVIEW ON METABOLIC SWITCH AND AUTOPHAGY.
Volume - 13 | Issue-1
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ONE-POT ENVIRONMENT FRIENDLY SYNTHESIS OF IMINE DERIVATIVE OF FURFURAL AND ASSESSMENT OF ITS ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL
Volume - 13 | Issue-1
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MODELING AND ANALYSIS OF MEDIA INFLUENCE OF INFORMATION DIFFUSION ON THE SPREAD OF CORONA VIRUS PANDEMIC DISEASE (COVID-19)
Volume - 13 | Issue-1
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INCIDENCE OF HISTOPATHOLOGICAL FINDINGS IN APPENDECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL IN TWO-YEAR TIME
Volume - 13 | Issue-1
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SEVERITY OF URINARY TRACT INFECTION SYMPTOMS AND THE ANTIBIOTIC RESISTANCE IN A TERTIARY CARE CENTRE IN PAKISTAN
Volume - 13 | Issue-1
THE EFFECTS OF MESENCHYMAL STEM CELLS AND THEIR DERIVED CONDITIONED MEDIA IN A HEPATOCELLULAR CARCINOMA MODEL
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Abstract
Background: Hepatocellular carcinoma (HCC) is the second greatest cause of cancer-related fatalities globally, with few possible treatments for studied cases with advanced HCC. As a result, there is a strong desire to develop novel alternatives therapies to cure HCC. Mesenchymal stem cells (MSCs) and MSC-derived conditioned medium (CM) has proven to be a fruitful strategy. The current research aimed to investigate role of human umblical cord MSCs (huc-MSC) & their derived CM in alleviation of HCC and clarifying related molecular mechanisms. Methods: Rats were formed into 4 groups: normal controls (group I), HCC group (II), HCC rats which received Mesenchymal stem cells from human umbilical cord blood (huc-MSCs group III), HCC treated with huc-MSCs-CM (CM group IV). Relative expression of hepatic miR 19a and the mRNA expression of PTEN were investigated using quantitative real-time PCR
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