Nurse-led interventions have emerged as a promising approach in the management of chronic diseases. This review article aims to explore the effectiveness of nurse-led interventions in chronic disease management. The role of nurses in delivering care to patients with chronic conditions has evolved significantly over the years, with a growing body of evidence supporting the positive impact of nurse-led interventions on patient outcomes. This review will examine various nurse-led interventions, including patient education, self-management support, medication management, and lifestyle counseling. The effectiveness of these interventions in improving patient adherence to treatment regimens, reducing hospital readmissions, and enhancing quality of life will be critically evaluated. Furthermore, this review will discuss the challenges and barriers faced by nurses in implementing these interventions, as well as potential strategies to overcome these obstacles. The importance of interdisciplinary collaboration and the integration of nurse-led interventions into existing healthcare systems will also be highlighted. Overall, this review aims to provide a comprehensive overview of the current evidence on the effectiveness of nurse-led interventions in chronic disease management, with the goal of informing healthcare providers, policymakers, and researchers about the potential benefits of incorporating nurses into the care of patients with chronic conditions.