INTRODUCTION: Interleukin 8 (IL-8) an important pro-inflammatory α-chemokine in inflammatory conditions like Periodontitis; it has been detected in gingival crevice / Gingival Crevicular Fluid (GCF). Monitoring of IL-8 levels in GCF may be an important marker for progression of periodontal disease activity. Thus, this study was conducted with an aim of determining GCF levels of IL-8 in periodontitis patients before and after non surgical periodontal therapy.