Increasing demand health care centers in front of great challenges toward continuity and maintain the level leadership and high-quality practices in primary health centers. Therefore, the problem of this study focuses on the application of acceptable leadership and quality practices in primary health care centers in Jeddah. The aim of the current paper seeks toward a better understanding of the effect of health care accreditation standards on the leadership and Quality Practices in Primary Health Care Centers in Jeddah to deliver efficient and effective medical services and to achieve patient satisfaction. The study applied the comparative quantitative approach between 68 primary health care centers include accredited and non-accredited institutions to analyze the data and test the study questions. Where the researcher used a questionnaire to collect data from administrative and health leaders in primary health centers in the city of Jeddah. According to the findings, accreditation was seen as having a beneficial impact on a number of different aspects of quality and leadership. In addition, a number of components of the accreditation had a good association with the quality of the outcomes. This featured a scale that was connected with growing participation, as well as a scale that was associated with leadership.