The aimed of this study is to explore the effect of Camellia Oleifera extract in the reproductive system of Pomacea canaliculata that can be help to control the negatives impact of P. canaliculata. The Golden apple snail (Pomacea canaliculata Lamarck) is a freshwater snail in the family of Ampullariidae. They had been introduced to Thailand in the 1980s and reported as severe rice pests in 1988. The department of agriculture of Thailand recommended using Niclosamide as a chemical molluscicide to control the snails. Natural resource such as Camellia Oleifera as one of the molluscicides plant should have a benefit to reduce the quantity of Golden apple snail because price friendly, environmental friendly, and safe for human. Camellia Oleifera has the special characteristic for golden apple snail because it’s high toxicity, specific performance to the target mollusk, convenience to prepare, and leaving no residuals in the environment. The extract of this plant has been applied for the static aquatic toxicology technique within 48 hours was performed in this experiment.