Males have a higher probability than women to develop prostate cancer which contributes considerably to higher death rates in men worldwide. Prostate cancer patients present with either an illness that is either isolated or progressed. Prior to this study, -3 polyunsaturated fatty acids & vitamin D were employed completely separately to evaluate the efficacy of prostate cancer treatment. However, numerous combination studies for prostate cancer have since been conducted.In comparison to individual therapy, the combinatory studies used in this review's analysis of trials in terms of ꞷ-3 fatty acids for the treatment of prostate cancer are quite effective at treating the disease. Because there may be significant commonalities between this combinational research on anticancer effects. In this review, the mechanics and efficacy of that will be addressed. Lastly, we contrast the combinations, finding that Vit D with ꞷ-3 fatty acids as well as easy at-home strength training, omega 3 stearidonic acid with doxorubicin, and 1,2-5 Dihydroxy vitamin-D with ꞷ-3 fatty acids are greater efficiency than to several other combinatory therapies with ꞷ-3 polyunsaturated fatty acids & individual therapies.