Background: Coronary artery disease (CAD) is a prevalent symptom of cardiovascular disease, which is a major worldwide health problem. Dyslipidemia significantly contributes to CAD development and progression. This study aimed to investigate whether a correlation exists between dyslipidemia, the different lipid levels and the density of coronary plaques in individuals presenting with chest pain with low to intermediate PTP for CAD, utilizing multidetector computed tomography (MDCT) imaging. Methods: this study is an observational cross-sectional study on one hundred patients with varying degrees of coronary stenosis , detected by MSCT in the cardiac CT Unit in Kobri Elkobba military specialized heart hospital , Cairo , Egypt . A full diagnostic workup was done for all patients , including history , laboratory tests , clinical examination , ECG and finally MSCT for identification of the coronary plaque characteristics , including plaque plaque density , morphology , presence of calcification and finally the severity of coronary stenosis . Results: The mean total cholesterol was 237.51 ± 60.03, LDL cholesterol was 145.75 ± 30. HDL cholesterol was 44.66 ± 15.29, triglycerides level was 176.81 ± 35.66. A highly significant negative correlation was found between cholesterol, LDL and triglycerides on one hand and the mean plaque density on the other hand ( P value < 0.001 ) , on the other hand a significant positive correlation was found between HDL cholesterol and the mean density of the plaques. A strong positive correlation was found between the total cholesterol, LDL, Triglycerides on one hand and the presence of non-calcified plaques , however a negative correlation was found between HDL and the presence of non-calcified plaques (P value <0.001) significant lesions were mostly present in patients with higher total cholesterol, LDL, triglycerides, LDL/HDL ratio. HDL level was significantly lower in the subgroup of significant lesions. Conclusion: There was a significant correlation between plasma lipid parameters on one hand and plaque density , presence of non-calcified plaques , as well as the significance of coronary stenosis on the other hand .