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Systemic Inflammatory Markers among Ulcerative Colitis Patients

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Elkhashab M. N., Amal A. Jouda , Hanaa A. Atwa, Mona ahmed Abdelmaksoud , Ali Refaat Abdelmonem
» doi: 10.53555/ecb/2023.12.Si12.197


Background: Ulcerative colitis is an idiopathic inflammatory condition of the colon which results in diffuse friability and superficial erosions on the colonic wall associated with bleeding. It is the most common form of inflammatory bowel disease worldwide. It characteristically involves inflammation restricted to the mucosa and submucosa of the colon. Typically, the disease starts in the rectum and extends proximally in a continuous manner. Inflammation is a complex dynamic protective response to cell injury, infection via microbes, trauma, or toxins in the vascularized tissues. The causative agent is diluted, destroyed, or isolated and a sequential cascade of molecular events is set that leads to repairing, healing, and reconstituting the damaged tissue. It is thoroughly characterized by the reaction in tissues and its microcirculation as clinically reflected by redness (erythema), heat (hyperemia), swelling (exudation), pain (through nerves and chemical mediators), and loss of function. The combined vascular and cellular inflammatory responses are triggered by inflammatory stimulus and mediated through chemical factors derived from some cells or blood plasma. Even the injured or dead tissues release mediators.

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