This paper involves synthesized of new some mannich bases derivative from ethers acetylene oxazoles, 2-[p-propyny-oxy] Benzyl -4,5-p-dimethyl phenyl oxazole, 2-[p-propyny-oxy] Benzyl-4,5-p-di chloro phenyl oxazole, 2-[ p-propyny-oxy ] Benzyl -4,5-p-diBromo phenyl oxazole , 2-[ p-propyny-oxy ] Benzyl -4-p-dimethyl amino phenyl -5-p-phenyl oxazole, 2-[ p-propyny-oxy ] Benzyl -4-p-methyl phenyl -5-p-phenyl oxazole, with diethyl amine and dimethyl amine yielded series of new mannich base the prepared compounds were characterized by FT-IR, 1HNMR, 13CNMR and anlysis elemental analysis and were tested for their antibacterial activity and study anti cauce.