The 1,3,4-oxadiazoles are observed as a significant class of heterocyclic substances having enormous range of biological actions, including fungicidal, herbicidal, etc. so they attracted the organic chemist very much. Since, the glycosides have a variety of pharmacological effects so in present study, we aimed to introduce a 1,3,4-oxadiazole group into glucopyranosyl moiety to design a series of novel glucopyranosyl derivatives of 1,3,4-oxadiazolone, as some oxadiazolone derivatives have been reported to exhibit antifungal activity.