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ISSN 2063-5346
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Synthesis, molecular docking and anti-depressant activity of 2-((4-nitrobenzyl) thio)-5-(4-nitrophenyl)-1,3,4-oxadiazole (JC-41) and 3-(3-acetyl-5-(2,4-dichlorophenyl)-2,3-dihydro1,3,4-oxadiazol-2-yl)-6-methylquinolin-2(1H)-one (JC-42) in mice model

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Amit Kumar Sharmaa , Tanveer Naveda*, Vikramdeep Mongab , Rajnish Kumar Malika
» doi: 10.48047/ecb/2023.12.8.599

Abstract

The present study was designed to test the anti-depressant effects of two synthesized compounds, JC-41 and JC-42 in a chronic unpredictable mild stress (CUMS)-induced depression in the mice. Initially, the compounds were synthesized and they were docked with MAO-A inhibitor Protein (2BXR).

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