Synthesis of new 1-(4-substituted phenylimino)-1-(4-hydroxyphenyl)propanes has been done successfully. These Schiff bases were converted to 3-ethyl-3(4-hydroxyphenyl)-2-(4-substituted phenyl)isothiazolidin-4-one and 3-chloro-1-(4-substituted phenyl)-4-ethyl-(4-hydroxyphenyl)azetidin-2-one derivatives with thioglycolic acid and chloroacetyl chloride/Et3N mixture in 1,4-dioxane, respectively. All the synthesized compounds were screened for biological activities.