This research includes synthesis of Sulphone base different new effective compounds against multi resistant pathogens is one of the major goals in current biomedical research. Among the heterocyclic compounds known in the literature for their various bioactivities are those with benzimidazole ring and those with sulfonamide moiety, which possess a wide range of medicinal properties. A novel series of benzimidazole-incorporated sulphonamide analogues were designed and synthesized with an effort to overcome the increasing antibiotic resistance. Benzimidazole and sulphonamides plays an important role in the medical field with so many pharmacological activities such as antimicrobial, anti-viral, anti-diabetic and anti-cancer activity. The potency and these clinically useful compounds in treatment of microbial infections and other activities encouraged the development of some more potent and significant compounds. In scheme-2 procedure are the planned reaction methodology for various derivatives of benzimidazole incorporated derivatives has been synthesized. Based on literature report about the importance of benzimidazole-sulphonamide derivatives as various drug molecules, we can expect some bioactive molecules from our synthesized compounds.