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ISSN 2063-5346
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Synthesis and in-vitro screening of Imatinib Schiff’s base as potential anticancer agents

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Kavita Sangwan, Balvinder Singh
» doi: 10.31838/ecb/2023.12.si4.052

Abstract

A series of azomethine compounds (Schiff’s bases) of Imatinib key intermediate N-(2,5- dimethylphenyl)-4-pyridin-3-ylpyrimidin-2-amine bearing2-chloroquinoline as heteroaryl motif was synthesised as Imatinibanalogues. The compounds were prepared by refluxing Imatinib key intermediate with 2-chloroquinoline aldehyde in ethanol as solvent. Spectraltechniques such as Fouriertransformation-IR, Proton-NMRalong with mass spectrometrywas applied for structure elucidation. In-vitroscreening for antiproliferative activity of compounds verses cell lines A549 and MCF7 were performed using MTT assay protocol. The results of antiproliferative activity revealed the compounds disclosedgood to moderate cell growth inhibition at conc. of 10 μM. All the compound exhibited percentage cell viability of 50% or less than 50% at concentration of 10μM

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