Chalcone derivative (E)-3-(4-butoxyphenyl)-1-(naphthalen-1-yl)prop-2-en-1-one (C23H22O2) crystallizes in monoclinic system with space group 'P21/c ' and unit cell parameters: a = 15.1595(14) Å, b = 7.6644(7) Å, c = 15.8634(15) Å, The crystal structure was solved using direct methods and refined by full matrix least squares procédures to a final R-factor of 0.0911 for 1591 observed reflections. The enone moiety adopts E conformation with respect to C12=C13 bond.The molecules in the unit cell are linked by weak C–H⋅⋅⋅O and π-π interactions. The molecule contains two C–H⋅⋅⋅O intramolecular interactions which stabilizes the crystal structure