The synthesis of bromo [1,4] benzodiazepine derivatives has been reported to be accomplished with ease and excellence. Using ethanol as a solvent, benzaldehyde, acetone, bromine and ethylene diamine were condensed to create benzodiazepine derivatives in the presence of sodium hydroxide as a catalyst. Shorter reaction times, an easier workup method, superior yields with simple recovery and make this process beneficial. For the purpose of characterizing the synthesized products, 1H and 13C nuclear magnetic resonance, Fourier transform infrared, and mass spectroscopy were employed.