.

ISSN 2063-5346
For urgent queries please contact : +918130348310

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2, 5-DISUBSTITUTED-1, 3, 4-OXADIAZOLES

Main Article Content

Ankita Dwivedi, Shweta Singh Verma, Ajay Kumar, Shivam Kumar, Sadhana Umar, Amna Parveen
» doi: 10.31838/ecb/2023.12.sa1.270

Abstract

Oxadiazole and its derivatives exhibit potent bactericidal activity against a wide range of microorganisms. A number of fresh 1,3,4-oxadiazole derivatives and analogues were created and their effectiveness as antimicrobials against a variety of pathogenic gram-positive and gram-negative organisms was examined. By using QSAR analysis, it is possible to correlate the physicochemical and structural characteristics of produced compounds with their antibacterial activity. The peptide deformylase inhibitory potential of the derivatives with strong antibacterial activity was examined using molecular docking experiments, which describe the interaction between the active derivatives and amino acid residues found in the active site of the enzyme. Oxadiazoles are common motifs in drug-like compounds and are regularly employed to replace the ester and amide functions with bioisosteric alternatives. 1,3,4-Oxadiazole and its derivatives have become significant pharmacological scaffolds, particularly in the treatment of cancer disease, because to their extensive and powerful activity. Several 1,3,4-oxadiazole compounds with di-, tri-, aromatic- and heterocyclic substitutions have been found to have strong anticancer properties. These substituted 1,3,4- oxadiazoles contributed to the discovery and development of anticancer drugs and have diverse mechanisms of action.

Article Details