1,2,4-Triazoles and their derivatives have a distinct place in the field of medicinal and pharmaceutical chemistry. They are utilised as starting materials in the synthesis of various heterocyclic compounds, many of which have important biological functions and diverse biological activities. They serve as the basic building blocks for the design and synthesis of several pharmaceutical molecules. As analgesic, antiseptic, antibacterial, antioxidant, antiurease, anti-inflammatory, diuretic, anticancer, anticonvulsant, antidiabetic, and antimigraine medicines, 1,2,4-triazole has a wide range of therapeutically attractive pharmacological candidates. Several medications with triazole structures have been created and proven, including fluconazole and ketoconazole. Their structure-activity relationship, biological activity and design strategy of diverse mono and poly substituted triazoles, all work to increase the level of acceptance of this heterocyclic ring in the field of medicinal chemistry. An awareness of the linkage between the chemistry of a certain molecule or combination of compounds and their interaction with the body is the basis of understanding in medicinal chemistry. The mode of action refers to the process through which the chemicals affect the biological system. This is used to maximise the beneficial effects of medications while minimising their negative side effects together with structural research. Hormones, vitamins, and biochemicals were produced as a result of research projects in medicinal chemistry, which helped to pave the way for the creation of medications for veterinary use.