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ISSN 2063-5346
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW L-LYSINE GLYCOSIDE DERIVATIVES

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Yamina Chergui[a] and Adil A. Othman
» doi: 10.17628/ECB.2016.5.330

Abstract

Novel glycosides 2-(1,5-diaminopentyl)-S-fructosyl-1,3,4-oxadiazole-5-thione , 3-(1,5-diaminopentyl)-5-S-glucosyl-1,2,4-triazole-5-thiole and 3-(1,5-diaminopentyl)-4-amino-5-S- or 4-N-glucosyl-1,2,4-triazole-5-thiole are obtained by reacting the appropriate azoles with Dfructose and D-glucose. All intermediates and final products are characterized by IR, 1H-NMR and 13C-NMR. The antimicrobial activities are assessed using the paper disk diffusion and broth dilution methods against Acinetobacter, Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus and Spongospora subterranean. Some of the synthesized compounds showed promising activity against microorganisms under test in comparison with commercially available antibiotics Polymixine and Oxytetracycline.

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